[読みたい論文] 水銀不要のClemmensen還元

Viewed: 03:33:56 in December 11, 2019

Posted: March 29, 2019

Controlled Reduction of Carboxamides to Alcohols or Amines by Zinc Hydrides (Ong, Derek Yiren; Yen, Zhihao; Yoshii, Asami; Revillo Imbernon, Julia; Takita, Ryo; Chiba, Shunsuke)
Angew. Chem. Int. Ed. 2019, 58 (15), 4992−4997.

Keywords: Zn; NaH; Clemmensen reduction

論文の趣旨とは違うかもしれませんが、こんなタイトルにしました。


ハロゲン化亜鉛/水素化ナトリウムによる、アミド化合物の還元反応について報告しています。

この論文の売りは、ハロゲン化亜鉛のハロゲンの種類によって生成物の化合物が異なること、つまり、ヨウ化亜鉛の場合には炭素−窒素結合が切断されてアルコールが生成し、塩化亜鉛の場合には炭素−酸素結合が切断されてアミンが生成することにあるのでしょう。

Graphical abstractの反応スキームは単純ですが、反応が綺麗に進行しているのか、それともアルコールとアミンが混ざって生成しているのか気になるので、読みたい論文に追加です。もちろん、なぜ結合が切断される場所が異なるのか、もです。

この記事を書いた人
「牧岡ふうふ堂」オーナー。博士(工学)。
酒都圏在住。
某地方の国立系工業大学でアシスタントをしていました。 専門は有機反応・金属錯体(主に希土類)・π共役系。
twitterアカウントは@makiokafufudo(お仕事用)、@ymakioka(個人用)です。

 

1952年はこんな年

人名反応など
Bamford−Stevens反応 [Doi 1]
Kabachnik−Fields反応 [Doi 1]
Kinnear−Perren反応 [Doi 1]
Lindlar還元 [Doi 1]
Perkow反応
ノーベル化学賞
分配クロマトグラフィーの開発およびその応用
(Archer John Porter Martin, Richard Laurence Millington Synge)
できごと
黄変米事件発生
十勝沖地震
日本文化放送協会(現在の文化放送)開局
硬貨式の公衆電話が登場
「鉄腕アトム」連載開始(手塚治虫)
競艇が初開催
ラジオドラマ「君の名は」放送
日本民間放送連盟(民放連)発足
「お茶漬け海苔」発売(永谷園)
ケーヨー(ケーヨーD2)設立
住民登録実施
東京国際空港(羽田空港)の業務再開
日本が国際通貨基金(IMF)に加盟
明星創刊(集英社)
ラジオ中国(中国放送)が開局
日本テレビ放送網(日本テレビホールディングス)設立
カムチャツカ地震(M9.0)
ロンドンスモッグ事件

 

きょうのどうぶつ

ここの画像を使用しています。

チャシロ、黒1号朝青龍と睨み合い中。この後ヘタレてゆっくり逃げる。

 

計算終わりました

 

あわせてどうぞ

SOHOのすすめ記事一覧 2019年
お仕事関係の記事のリストです(2019年)。

読みたい論文シリーズ − 2019年1Q
読みたいけと読んでいない論文を、構造式を描きながら紹介します(2019年1〜3月)。

 

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著者に注目。
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